Pre-eclampsia and PPCM

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The following studies discuss PPCM, Peripartum Cardiomyopathy as a vascular disases and the possible role of anti-angiogenic signalling in its development, potentially explaining the role of pre-eclampsia and multiple births in the development of PPCM.

Harvard University Study

A Harvard Medical School–led team has shown that a soluble form of FLT1 causes about one-third of peripartum cardiomyopathy cases—those associated with pre-eclampsia. Ongoing studies are seeking to identify small molecule inhibitors of the protein and determine whether the mechanism also underlies the other two-thirds of cases.


Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

"These data indicate that PPCM is mainly a vascular disease, caused by excess anti-angiogenic signalling in the peripartum period. The data also explain how late pregnancy poses a threat to cardiac homeostasis, and why pre-eclampsia and multiple gestation are important risk factors for the development of PPCM."

Post Partum Cardiomyopathy / Peripartum Cardiomyopathy as a Vascular Disease

Recent study explaining how PPCM could be a vascular disease. During pregnancy a woman's vascular system increases in size to accommodate and support the growth of a baby and this study seeks to explain how otherwise healthy women could develop heart failure in pregnancy due to abnormalities in their vascular system.

About has been developed to raise awareness about heart failure in pregnancy (PPCM) and provide support for heart sisters through storytelling and friendship. How to Join - Join as a heart sister, cardiologist or relative of a deceased heart sister and add yourself to a map and directory listing.

Read PPCM Stories from heart sisters or read about PPCM Recovery

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